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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
Theophylline inhibited the phagocytosis of latex beads by Acanthamoeba castellanii (Neff). The cells recovered the ability to engulf beads after 1-2 hr of exposure to theophylline. Cells which have been exposed to 25 mM theophylline for a period of inhibition and recovery were not inhibited further by incubation with a fresh medium containing the same concentration of theophylline. However, the medium in which the cells recovered was as effective as a fresh medium in inhibiting phagocytosis in a fresh batch of cells, suggesting that the development of insensitivity to theophylline inhibition resides with the cells themselves. Dibutyryl cyclic AMP also inhibited bead uptake.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
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pubmed:issn |
0022-3921
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:180290-Amoeba,
pubmed-meshheading:180290-Animals,
pubmed-meshheading:180290-Bucladesine,
pubmed-meshheading:180290-Culture Media,
pubmed-meshheading:180290-Cyclic AMP,
pubmed-meshheading:180290-Phagocytosis,
pubmed-meshheading:180290-Theophylline,
pubmed-meshheading:180290-Time Factors
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pubmed:year |
1976
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pubmed:articleTitle |
Inhibition by theophylline of phagocytosis in Acanthamoeba castellanii.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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