Linked Life Data

18028029

Source:http://linkedlifedata.com/resource/pubmed/id/18028029

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-11-21
pubmed:abstractText
Cytochromes P450 (CYPs) are versatile oxidase catalysts that play pivotal roles in drug metabolism. They are highly regarded as biotechnological tools for their capacity to perform regio- and stereo-selective oxidations. Human CYPs source electrons for oxygen activation from one or more separate redox partner enzymes. However, several CYP enzymes are now known in which the CYP is covalently linked to a reductase system. Some of these systems offer distinct advantages over typical CYPs as efficient, self-contained units capable of important biotransformations, including synthesis of high value chemicals and pharmaceuticals. Protein engineering has been widely applied to produce variant CYP fusions with desirable activities. The review focuses on the nature and diversity of CYP/redox partner fusion enzymes and their biocatalytic potential.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1742-5255
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
847-63
pubmed:dateRevised
2009-11-16
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.
pubmed:affiliation
University of Manchester, Manchester Interdisciplinary Biocentre, Faculty of Life Sciences, 131 Princess Street, Manchester M1 7DN, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't