Source:http://linkedlifedata.com/resource/pubmed/id/18027070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-2-16
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| pubmed:abstractText |
A relationship between apolipoprotein E (Apo E) genotype and angiotensin-converting enzyme (ACE) insertion-deletion (Ins-Del) mutation and stroke was suggested. We investigated the association of Apo E4 and ACE Ins/Del genotypes with stroke risk and changes in serum lipids in 228 consecutive Tunisian stroke patients, and 323 age-and gender-matched controls. Comparable frequencies of ACE Ins/Del alleles were seen between patients and controls. The prevalence of Apo epsilon3 allele and Apo E3/E3 were lower (P < 0.001), while the frequency of Apo epsilon4 allele and epsilon4-containing genotypes (E3/E4 and E4/E4) were elevated (P < 0.001) among patients. Higher proportion of Apo E4-carrying + ACE Del/Del positive cases were seen in young (<50 years) patients (P = 0.012), and was associated with large vessel stroke (P = 0.035). Mean serum cholesterol, LDL, HDL, and triglycerides were comparable between E4-containing and no E4-containing and ACE Del/Del-positive patients. Apo E4 and ACE Del/Del genotype combination substantially increase stroke risk, supporting the notion that interactions of multiple gene variants influence stroke pathogenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0929-5305
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
27
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
68-74
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| pubmed:meshHeading |
pubmed-meshheading:18027070-Age Factors,
pubmed-meshheading:18027070-Aged,
pubmed-meshheading:18027070-Alleles,
pubmed-meshheading:18027070-Apolipoprotein E3,
pubmed-meshheading:18027070-Apolipoprotein E4,
pubmed-meshheading:18027070-Brain Ischemia,
pubmed-meshheading:18027070-Case-Control Studies,
pubmed-meshheading:18027070-Comorbidity,
pubmed-meshheading:18027070-Epigenesis, Genetic,
pubmed-meshheading:18027070-Female,
pubmed-meshheading:18027070-Gene Frequency,
pubmed-meshheading:18027070-Genotype,
pubmed-meshheading:18027070-Humans,
pubmed-meshheading:18027070-Intracranial Arteriosclerosis,
pubmed-meshheading:18027070-Lipids,
pubmed-meshheading:18027070-Male,
pubmed-meshheading:18027070-Middle Aged,
pubmed-meshheading:18027070-Peptidyl-Dipeptidase A,
pubmed-meshheading:18027070-Polymorphism, Genetic,
pubmed-meshheading:18027070-Risk Factors,
pubmed-meshheading:18027070-Sequence Deletion,
pubmed-meshheading:18027070-Tunisia
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| pubmed:year |
2009
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| pubmed:articleTitle |
Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease.
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| pubmed:affiliation |
Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.
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| pubmed:publicationType |
Journal Article
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