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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1992-4-24
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pubmed:abstractText |
The goals of the MELANIE project are to determine if disease-associated patterns can be detected in high resolution two-dimensional polyacrylamide gel electrophoresis (HR 2D-PAGE) images and if a diagnosis can be established automatically by computer. The ELSIE/MELANIE system is a set of computer programs which automatically detect, quantify, and compare protein spots shown on HR 2D-PAGE images. Classification programs help the physician to find disease-associated patterns from a given set of two-dimensional gel electrophoresis images and to form diagnostic rules. Prototype expert systems that use these rules to establish a diagnosis from new HR 2D-PAGE images have been developed. They successfully diagnosed cirrhosis of the liver and were able to distinguish a variety of cancer types from biopsies known to be cancerous.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0173-0835
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
12
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
722-35
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1802690-Biopsy,
pubmed-meshheading:1802690-Cluster Analysis,
pubmed-meshheading:1802690-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:1802690-Expert Systems,
pubmed-meshheading:1802690-Humans,
pubmed-meshheading:1802690-Image Processing, Computer-Assisted,
pubmed-meshheading:1802690-Neoplasms,
pubmed-meshheading:1802690-Peptide Mapping,
pubmed-meshheading:1802690-Software
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pubmed:year |
1991
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pubmed:articleTitle |
The MELANIE project: from a biopsy to automatic protein map interpretation by computer.
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pubmed:affiliation |
Numeric Imaging Group, Geneva University Hospital, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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