Linked Life Data

1802642

Source:http://linkedlifedata.com/resource/pubmed/id/1802642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-4-29
pubmed:abstractText
The heart and viscera of vertebrates are formed from primordia that are apparently bilaterally symmetrical. This symmetry is broken during development, yielding organs that develop characteristic asymmetries along the left-right axis. Results from three lines of experimentation on embryos of the amphibian Xenopus laevis indicate that left-right asymmetries are established early in development and that cellular interactions transmit left-right information from one primordium to another. First, a cytoplasmic rearrangement that occurs during the first cell cycle after fertilization may establish left-right asymmetry in some regions of the embryo. Second, a variety of experimental results indicate that embryonic ectoderm or its basal extracellular matrix may transmit left-right axial information to cardiac mesoderm and visceral endoderm. Third, inhibition of proteoglycan synthesis during a narrow period of development, concurrent with the migration of the cardiac primordia to the ventral midline, prevents asymmetrical development of the heart.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0300-5208
pubmed:author
pubmed:issnType
Print
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-76; discussion 176-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Development of the left-right axis in amphibians.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.