Linked Life Data

18024584

Source:http://linkedlifedata.com/resource/pubmed/id/18024584

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
48
pubmed:dateCreated
2007-11-29
pubmed:abstractText
Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be involved in chronic neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. To explore the mechanism of autophagy and identify small molecules that can activate it, we developed a series of high-throughput image-based screens for small-molecule regulators of autophagy. This series of screens allowed us to distinguish compounds that can truly induce autophagic degradation from those that induce the accumulation of autophagosomes as a result of causing cellular damage or blocking downstream lysosomal functions. Our analyses led to the identification of eight compounds that can induce autophagy and promote long-lived protein degradation. Interestingly, seven of eight compounds are FDA-approved drugs for treatment of human diseases. Furthermore, we show that these compounds can reduce the levels of expanded polyglutamine repeats in cultured cells. Our studies suggest the possibility that some of these drugs may be useful for the treatment of Huntington's and other human diseases associated with the accumulation of misfolded proteins.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-10394369, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-11060023, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-11099404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-11454456, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-11911884, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-12072431, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-122926, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-12540902, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-12782577, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-12871771, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-14536056, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-14699058, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-15325584, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-15596714, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-15695335, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-15905882, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-15928708, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-16200202, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-16226444, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-16469695, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-17118264, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-17224628, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-17244528, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-17311494, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-17321123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-4544026, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-4566123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-4992598, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-6147393, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-6641796, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-8183255, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-8761415, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-9072974, http://linkedlifedata.com/resource/pubmed/commentcorrection/18024584-9545135
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Fluspirilene, http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Loperamide, http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Mycotoxins, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol Phosphates, http://linkedlifedata.com/resource/pubmed/chemical/Pimozide, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus, http://linkedlifedata.com/resource/pubmed/chemical/Small Molecule Libraries, http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Trifluoperazine, http://linkedlifedata.com/resource/pubmed/chemical/light chain 3, human, http://linkedlifedata.com/resource/pubmed/chemical/phosphatidylinositol..., http://linkedlifedata.com/resource/pubmed/chemical/polyglutamine, http://linkedlifedata.com/resource/pubmed/chemical/tremortin
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
27
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19023-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
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