Linked Life Data

18024035

Source:http://linkedlifedata.com/resource/pubmed/id/18024035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-12-24
pubmed:abstractText
In the present study, we investigate the effects of an extract isolated from traditional Chinese medicine Zi-Shen Pill (ZSPE) on benign prostatic hyperplasia (BPH) in rats induced by testosterone after castration. A total of 50 rats were equally divided into five groups: Group 1 served as control (sham-operated group); Group 2 was model group; Group 3 and Group 4 animals were administered with ZSPE at dose levels of 300 mg/kg and 600 mg/kg; Group 5 was served as positive control group and treated with finasteride at a dose of 1 mg/kg. The drugs were administered orally once a day for 28 days consecutively. The prostate weight, prostatic index, and serum dihydrotestosterone (DHT) levels were significantly reduced and the pathological changes in BPH were also by ameliorated ZSPE. Immunohistochemical examination revealed that the expressions of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in prostate were inhibited by ZSPE treatment, whereas the levels of transforming growth factor-beta1 (TGF-beta1) were increased. These results suggest that ZSPE has a definite inhibitory effect on BPH and might be an alternative medicine for treatment of human BPH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0378-8741
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-8
pubmed:meshHeading
pubmed-meshheading:18024035-Administration, Oral, pubmed-meshheading:18024035-Anemarrhena, pubmed-meshheading:18024035-Animals, pubmed-meshheading:18024035-Cinnamomum aromaticum, pubmed-meshheading:18024035-Drugs, Chinese Herbal, pubmed-meshheading:18024035-Enzyme Inhibitors, pubmed-meshheading:18024035-Fibroblast Growth Factor 2, pubmed-meshheading:18024035-Finasteride, pubmed-meshheading:18024035-Gene Expression Regulation, pubmed-meshheading:18024035-Male, pubmed-meshheading:18024035-Medicine, Chinese Traditional, pubmed-meshheading:18024035-Phellodendron, pubmed-meshheading:18024035-Prostatic Hyperplasia, pubmed-meshheading:18024035-Rats, pubmed-meshheading:18024035-Rats, Sprague-Dawley, pubmed-meshheading:18024035-Transforming Growth Factor beta1, pubmed-meshheading:18024035-Vascular Endothelial Growth Factor A
pubmed:year
2008
pubmed:articleTitle
Inhibitory effect of traditional Chinese medicine Zi-Shen Pill on benign prostatic hyperplasia in rats.
pubmed:affiliation
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 GuoHe Road, Shanghai 200433, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't