Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-12-6
pubmed:abstractText
The escalating obesity/diabetes epidemic is an important health-care issue that has crucial socio-economic ramifications. The complications of diabetes/obesity phenotypes extend to the central nervous system (CNS), including the hippocampus, a brain region that is particularly vulnerable to hyperglycemia and insulin resistance. Deficits in hippocampal synaptic plasticity observed in diabetes ultimately have deleterious consequences upon cognitive function. For example, recent studies using brain imaging technologies have identified cerebral atrophy in diabetic patients, suggesting that the neuroanatomical changes observed in experimental models of diabetes may accurately reflect what is occurring in the clinical setting. Deficits in insulin receptor (IR) signaling and impairments in hypothalamic-pituitary-adrenal (HPA) axis function also contribute to the neurological complications of diabetes phenotypes. The pathophysiological similarities between diabetes and stress-related mood disorders suggest that common mechanistic mediators may be involved in the etiology and progression of the neurological complications of these disorders. When combined with the accumulating evidence from pre-clinical models, these data support the hypothesis that a long-term consequence of diabetes/obesity phenotypes is accelerated brain aging that results in neuropsychological deficits and increased vulnerability to co-morbidities such as depressive illness.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10480763, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10574963, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10591291, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10599761, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10713291, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10819245, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-10832792, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-11005876, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-11222059, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-11384623, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-11445137, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-11821903, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12137925, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12150780, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12377298, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12420363, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12502506, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-12505754, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-14595538, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-14706419, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-15094070, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-15581671, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-15617768, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-15745842, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16226381, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16287721, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16300445, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16316783, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16409563, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16443764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-1647314, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16553617, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16567535, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16595758, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16689680, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-16807785, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-17054452, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-17334649, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-17407648, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-17426095, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-17430239, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-2249648, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-2819907, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-3193850, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-8295654, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-8800646, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-9263195, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-9284058, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-9659988, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-9661998, http://linkedlifedata.com/resource/pubmed/commentcorrection/18023616-9685609
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1471-4892
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
633-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Insulin signaling effects on memory and mood.
pubmed:affiliation
Department of Pharmacology, Physiology and Neuroscience, School of Medicine, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29208, USA. preagan@med.sc.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural