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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
A functional variant in the MDM2 promoter (a T/G substitution, SNP309) was found to be associated with increased expression of MDM2 gene products and at significantly earlier age onset of tumors in both hereditary Li-Fraumeni individuals and sporadic cancer patients. We tested the hypothesis that this functional variant was associated with either risk or early age diagnosis of cervical cancer in a Brazilian population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
1525-1500
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18023538-Adult,
pubmed-meshheading:18023538-Age of Onset,
pubmed-meshheading:18023538-Brazil,
pubmed-meshheading:18023538-Carcinoma,
pubmed-meshheading:18023538-Female,
pubmed-meshheading:18023538-Humans,
pubmed-meshheading:18023538-Immunoblotting,
pubmed-meshheading:18023538-Middle Aged,
pubmed-meshheading:18023538-Papillomavirus Infections,
pubmed-meshheading:18023538-Polymerase Chain Reaction,
pubmed-meshheading:18023538-Polymorphism, Single Nucleotide,
pubmed-meshheading:18023538-Promoter Regions, Genetic,
pubmed-meshheading:18023538-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:18023538-Uterine Cervical Neoplasms
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pubmed:year |
2007
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pubmed:articleTitle |
No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil.
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pubmed:affiliation |
Programa de Pós-Graduação em Genética e Biologia Molecular, Universidade Federal do Rio Grande do Norte, Lagoa Nova, CEP:59072-970 Natal, RN, Brasil. vmrosely@yahoo.com.br
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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