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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017817,
umls-concept:C0020275,
umls-concept:C0031511,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0162638,
umls-concept:C0220781,
umls-concept:C1280500,
umls-concept:C1527240,
umls-concept:C1883254
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pubmed:issue |
2-3
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Oxidized glutathione C(60) derivative has been synthesized and characterized in our research. As a novel derivative of C(60), the glutathione C(60) derivative is soluble in dimethylsulfoxide, dimethylformamide and dimethylacetamide. Rat pheochromocytoma (PC12) cells are treated with hydrogen peroxide and underwent cytotoxicity; apoptotic death is determined by MTT assay, flow cytometry analysis, PI/Hoechst 33342 staining and glutathione assay. The results suggest that glutathione C(60) derivative has the potential to prevent oxidative stress-induced cell death without evident toxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
429
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-6
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pubmed:meshHeading |
pubmed-meshheading:18022764-Animals,
pubmed-meshheading:18022764-Antioxidants,
pubmed-meshheading:18022764-Apoptosis,
pubmed-meshheading:18022764-Benzimidazoles,
pubmed-meshheading:18022764-Biological Assay,
pubmed-meshheading:18022764-Cytotoxins,
pubmed-meshheading:18022764-Dimerization,
pubmed-meshheading:18022764-Flow Cytometry,
pubmed-meshheading:18022764-Fullerenes,
pubmed-meshheading:18022764-Glutathione,
pubmed-meshheading:18022764-Hydrogen Peroxide,
pubmed-meshheading:18022764-Molecular Structure,
pubmed-meshheading:18022764-Nerve Degeneration,
pubmed-meshheading:18022764-Neurons,
pubmed-meshheading:18022764-Neuroprotective Agents,
pubmed-meshheading:18022764-Oxidative Stress,
pubmed-meshheading:18022764-PC12 Cells,
pubmed-meshheading:18022764-Rats,
pubmed-meshheading:18022764-Tetrazolium Salts
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of glutathione C60 derivative and its protective effect on hydrogen peroxide-induced apoptosis in rat pheochromocytoma cells.
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pubmed:affiliation |
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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