Source:http://linkedlifedata.com/resource/pubmed/id/18022570
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2007-11-20
|
| pubmed:abstractText |
Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, we have little information on the clinical association of various human leukocyte antigen (HLA) alleles with CMV infection. We reviewed medical records of 60 patients who underwent allo-HSCT. The effect of the 7 most frequent HLA alleles on the incidence of CMV infection and disease was analyzed, including HLA-A*02, A*11, A*24, B*13, B*40(60), DRB1*15, and DRB1*09. All the patients were monitored for CMV infection at least once weekly within 3 months. CMV infection was found in 38 (63.3%) patients on a median of day 36 (range: 16-89). Diagnosis of CMV disease was established in 6 (10.0%) patients, comprising pneumonia (n = 2), enterocolitis (n = 2), and hemorrhagic cystitis (n = 2). CMV disease was successfully treated using ganciclovir or foscarnet combined with immune globulins in 4 patients. The other 2 patients died without improvement of CMV disease. In multivariate analysis, grade II-IV acute graft-versus-host disease (aGVHD), CMV seronegative donors, and HLA-DRB1*09 were associated with increased incidence of CMV infection and disease after allo-HSCT. We suggest that more cautions should be taken to prevent CMV infection in patients with HLA-DRB1*09 after allo-HSCT.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1083-8791
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1417-21
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:18022570-Adolescent,
pubmed-meshheading:18022570-Adult,
pubmed-meshheading:18022570-Child,
pubmed-meshheading:18022570-Child, Preschool,
pubmed-meshheading:18022570-Cytomegalovirus Infections,
pubmed-meshheading:18022570-Female,
pubmed-meshheading:18022570-Genetic Predisposition to Disease,
pubmed-meshheading:18022570-Graft vs Host Disease,
pubmed-meshheading:18022570-HLA-DR Antigens,
pubmed-meshheading:18022570-HLA-DRB1 Chains,
pubmed-meshheading:18022570-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:18022570-Humans,
pubmed-meshheading:18022570-Incidence,
pubmed-meshheading:18022570-Infant,
pubmed-meshheading:18022570-Infant, Newborn,
pubmed-meshheading:18022570-Male,
pubmed-meshheading:18022570-Middle Aged,
pubmed-meshheading:18022570-Retrospective Studies,
pubmed-meshheading:18022570-Risk Factors,
pubmed-meshheading:18022570-Transplantation, Homologous
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
HLA-DRB1*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation.
|
| pubmed:affiliation |
Department of Hematology, Peking University First Hospital, Beijing, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|