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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
29
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4. Hipk4 is expressed in lung and in white adipose tissue and encodes a 616 amino acid protein that includes a serine/threonine kinase domain. We demonstrate that HIPK4 could phosphorylate human p53 protein at serine 9, both in vitro and in vivo. Among known p53-responsive promoters, activity of the human survivin promoter, which is repressed by p53, was decreased by HIPK4 in p53 functional A549 cells. Human BCL2-associated X protein-promoter activity was not affected. These findings suggest that phosphorylation of p53 at serine 9 is important for p53 mediated transcriptional repression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/BIRC5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Apoptosis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
581
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5649-57
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18022393-Amino Acid Sequence,
pubmed-meshheading:18022393-Animals,
pubmed-meshheading:18022393-Catalysis,
pubmed-meshheading:18022393-Cell Differentiation,
pubmed-meshheading:18022393-Cell Proliferation,
pubmed-meshheading:18022393-Cloning, Molecular,
pubmed-meshheading:18022393-DNA, Complementary,
pubmed-meshheading:18022393-Humans,
pubmed-meshheading:18022393-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:18022393-Mice,
pubmed-meshheading:18022393-Microtubule-Associated Proteins,
pubmed-meshheading:18022393-Molecular Sequence Data,
pubmed-meshheading:18022393-Neoplasm Proteins,
pubmed-meshheading:18022393-Promoter Regions, Genetic,
pubmed-meshheading:18022393-Protein-Serine-Threonine Kinases,
pubmed-meshheading:18022393-Sequence Alignment,
pubmed-meshheading:18022393-Serine,
pubmed-meshheading:18022393-Tumor Suppressor Protein p53,
pubmed-meshheading:18022393-bcl-2-Associated X Protein
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pubmed:year |
2007
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pubmed:articleTitle |
Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.
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pubmed:affiliation |
Division of Gene Structure and Function, Research Center for Genomic Medicine, Saitama Medical University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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