Linked Life Data

18022385

Source:http://linkedlifedata.com/resource/pubmed/id/18022385

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-12-6
pubmed:abstractText
The malignancy of alveolar rhabdomyosarcoma (ARMS) has been linked to expression of the PAX3-FKHR chimeric gene. To understand the effect of this gene, we used RNAi to knock down its expression (without affecting the expressions of either PAX3 or FKHR) in human ARMS cell lines. Down-regulating PAX3-FKHR caused (a) tumor cells to accumulate in the G1 phase, inhibiting the rate of cellular proliferation, (b) a reduction in the levels of the MET, reducing cell motility stimulated by HGF, and (c) induction of the myogenic differentiation gene, myogenin, and muscle differentiation (morphologic change and the expression of muscle specific proteins, desmin, and myosin heavy chain). These results suggest that PAX3-FKHR in ARMS cells promotes malignant phenotypes such as proliferation, motility, and to suppress differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
18
pubmed:volume
365
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
568-74
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
pubmed:affiliation
Department of Pediatrics, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramchi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't