Linked Life Data

18020977

Source:http://linkedlifedata.com/resource/pubmed/id/18020977

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Parkinson's disease (PD) is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer's disease, affecting an increasing number of patients due to the demographic trend towards an aged population. The etiology of sporadic PD is only poorly understood, thus, the identification of genes that are responsible for familial variants of PD was a major breakthrough. Insight into the function of these genes can promote the understanding of the molecular causes of PD and help to focus research on key biochemical pathways. Mutations in the parkin gene, encoding an E3 ubiquitin ligase, are responsible for the majority of autosomal recessive PD. Recent research revealed that parkin has a remarkably wide neuroprotective capacity, preventing cell death under various stress conditions. This property makes parkin an attractive target for therapeutic strategies to prevent or halt the loss of dopaminergic neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1744-7631
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1543-52
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The parkin protein as a therapeutic target in Parkinson's disease.
pubmed:affiliation
Ludwig-Maximilians-University, Adolf-Butenandt-Institute, Department of Biochemistry, Schillerstrasse 44, 80336 Munich, Germany. Konstanze.Winklhofer@med.uni-muenchen.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't