Linked Life Data

1802035

Source:http://linkedlifedata.com/resource/pubmed/id/1802035

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-4-24
pubmed:databankReference
pubmed:abstractText
The alpha-tubulin cDNA clone, pTUB5 (1536 bp), contains the entire coding sequence for an alpha-tubulin of 450 amino acids (mol. wt. 50,000) and is the first tubulin sequence to be reported for a fish. The transcript encoded by pTUB5 showed testis-specific expression. Its gene appears to be present at a single copy number in the trout tubulin multigene family. Comparison of the TUB5 amino acid sequence to the murine testis-specific alpha-tubulin (M alpha 3/7) revealed that eight of ten murine isotype-specific amino acid substitutions were in common. Certain of these substitutions are also conserved in other testis-specific alpha-tubulins and in alpha-tubulins of certain protozoans with flagella. The conservation of specific amino acids at these positions suggests that they may have important structural and or functional roles in the microtubules of axonemes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1042-5179
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The predicted protein sequence of a fish testis-specific alpha-tubulin cDNA shows conservation of isotype-specific amino acid substitutions.
pubmed:affiliation
Department of Medical Biochemistry, University of Calgary, Alberta, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't