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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1992-4-21
|
| pubmed:abstractText |
Three neurotoxic fractions, lethal to mice, were isolated from the venom of the spider Phoneutria nigriventer, by gel filtration and reverse phase chromatography (Phoneutria toxins 1, 2 and 3). These toxins have mol. wts in the range 6000-9000, and have different amino acid compositions and N-terminal amino acid sequences. The toxins also differ in the lethality and signs they cause in mice after intracerebro-ventricular injection. The median LD50 being respectively for the whole venom, toxins 1, 2 and 3, 47 +/- 5 micrograms, 45 +/- 4 micrograms, 1.7 +/- 0.7 micrograms and 137 +/- 10 micrograms/kg mouse. Toxins 1 and 2 induce excitatory symptoms in mice and toxin 3 a flaccid paralysis with an ED50 of 40 +/- 5 micrograms/kg mouse as measured also by intracerebro-ventricular injection. The presence in the venom of a non-neurotoxic, smooth muscle active peptide is also described.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0041-0101
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1225-33
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1801316-Amino Acid Sequence,
pubmed-meshheading:1801316-Amino Acids,
pubmed-meshheading:1801316-Animals,
pubmed-meshheading:1801316-Chromatography, Gel,
pubmed-meshheading:1801316-Chromatography, Liquid,
pubmed-meshheading:1801316-Female,
pubmed-meshheading:1801316-Guinea Pigs,
pubmed-meshheading:1801316-Injections, Intraventricular,
pubmed-meshheading:1801316-Lethal Dose 50,
pubmed-meshheading:1801316-Mice,
pubmed-meshheading:1801316-Molecular Sequence Data,
pubmed-meshheading:1801316-Molecular Weight,
pubmed-meshheading:1801316-Muscle, Smooth,
pubmed-meshheading:1801316-Muscle Contraction,
pubmed-meshheading:1801316-Neurotoxins,
pubmed-meshheading:1801316-Peptides,
pubmed-meshheading:1801316-Spider Venoms,
pubmed-meshheading:1801316-Spiders
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Isolation of neurotoxic peptides from the venom of the 'armed' spider Phoneutria nigriventer.
|
| pubmed:affiliation |
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|