Source:http://linkedlifedata.com/resource/pubmed/id/18008250
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2007-11-16
|
| pubmed:abstractText |
After a primary series of 3 doses, it was found that a 9-valent pneumococcal conjugate vaccine no longer reduces nasopharyngeal colonization by vaccine serotypes in children 5.3 years of age. In addition, human immunodeficiency virus (HIV)-infected children (n=81) had a higher prevalence of colonization by Streptococcus pneumoniae and Haemophilus influenzae (71.6% and 74.1%, respectively) than did HIV-uninfected children (n=271; 50.9% and 52.0%, respectively), suggesting that increased colonization may contribute to the greater burden of pneumococcal disease in HIV-infected children. Inverse associations between colonization by S. pneumoniae and colonization by Staphylococcus aureus and between colonization by S. aureus and colonization by H. influenzae were observed only in HIV-uninfected children, possibly as a result of suboptimal adaptive immunity after previous colonization in HIV-infected children.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
196
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1662-6
|
| pubmed:meshHeading |
pubmed-meshheading:18008250-AIDS-Related Opportunistic Infections,
pubmed-meshheading:18008250-Child,
pubmed-meshheading:18008250-Child, Preschool,
pubmed-meshheading:18008250-Female,
pubmed-meshheading:18008250-HIV Seronegativity,
pubmed-meshheading:18008250-Haemophilus Infections,
pubmed-meshheading:18008250-Haemophilus influenzae,
pubmed-meshheading:18008250-Humans,
pubmed-meshheading:18008250-Male,
pubmed-meshheading:18008250-Nasopharynx,
pubmed-meshheading:18008250-Pneumococcal Infections,
pubmed-meshheading:18008250-Pneumococcal Vaccines,
pubmed-meshheading:18008250-Prevalence,
pubmed-meshheading:18008250-Staphylococcal Infections,
pubmed-meshheading:18008250-Staphylococcus aureus,
pubmed-meshheading:18008250-Streptococcus pneumoniae,
pubmed-meshheading:18008250-Time Factors,
pubmed-meshheading:18008250-Vaccines, Conjugate
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae--and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization--in HIV-Infected and HIV-uninfected children.
|
| pubmed:affiliation |
University of the Witwatersrand/Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Bertsham, South Africa. madhis@hivsa.com
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|