Source:http://linkedlifedata.com/resource/pubmed/id/18006936
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
Some prospective epidemiologic studies have suggested that a low plasma cholesterol level may be associated with increased risk of cancer. Certain sequence variants in the proprotein convertase subtilisin/kexin type 9 serine protease gene (PCSK9) are associated with lifelong low total and LDL cholesterol. We therefore analyzed the association of PCSK9 variation with incidence of cancer between 1987 and 2000 in a prospective study (n=13,250). The frequency of the PCSK9 variants studied was 2.4% in blacks and 3.2% in whites. Neither was associated with increased cancer incidence: age- and sex-adjusted hazard ratios were 0.66 [95% confidence interval (95% CI), 0.31-1.39] in blacks and 0.77 (95% CI, 0.54-1.09) in whites. Low baseline total or LDL cholesterol levels in 1987 to 1989 were also not statistically significantly associated with incident cancer: multivariable-adjusted hazard ratios for the lowest compared with the highest quartiles of LDL cholesterol were 1.05 (95% CI, 0.78-1.40) in blacks and 1.16 (95% CI, 0.99-1.36) in whites. These data suggest that a lifelong low cholesterol concentration, as reflected by these PCSK9 variants, does not increase risk of cancer.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55015,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55016,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55018,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55019,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55020,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55021,
http://linkedlifedata.com/resource/pubmed/grant/N01-HC-55022,
http://linkedlifedata.com/resource/pubmed/grant/R03-CA65473
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1055-9965
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2455-8
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pubmed:meshHeading |
pubmed-meshheading:18006936-African Continental Ancestry Group,
pubmed-meshheading:18006936-Cholesterol, LDL,
pubmed-meshheading:18006936-Cohort Studies,
pubmed-meshheading:18006936-European Continental Ancestry Group,
pubmed-meshheading:18006936-Female,
pubmed-meshheading:18006936-Humans,
pubmed-meshheading:18006936-Incidence,
pubmed-meshheading:18006936-Male,
pubmed-meshheading:18006936-Middle Aged,
pubmed-meshheading:18006936-Neoplasms,
pubmed-meshheading:18006936-Prospective Studies,
pubmed-meshheading:18006936-Serine Endopeptidases,
pubmed-meshheading:18006936-United States
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pubmed:year |
2007
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pubmed:articleTitle |
Sequence variation in proprotein convertase subtilisin/kexin type 9 serine protease gene, low LDL cholesterol, and cancer incidence.
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pubmed:affiliation |
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA. folsom@epi.umn.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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