rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22 Pt 1
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
p16(INK4a) has been appreciated as a key regulator of cell cycle progression and senescence. Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, centrosomal dysfunction, a sustained stress response, and, most recently, a dysregulation of chromatin remodeling and DNA methylation. These data suggest that cells that lack p16(INK4a) activity would be at high risk for breast cancer development and may exhibit an increased frequency of DNA methylation events in early cancer.
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pubmed:grant |
|
pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BakerJoseph CJCJr,
pubmed-author:BeanGregory RGR,
pubmed-author:BranderDanielle M UDM,
pubmed-author:BroadwaterGloriaG,
pubmed-author:BrysonAndrew DAD,
pubmed-author:CaseNatalie RNR,
pubmed-author:DietzeEricE,
pubmed-author:FabianCarol JCJ,
pubmed-author:GauthierMonaM,
pubmed-author:GoldenbergVanessaV,
pubmed-author:IbarraCatherineC,
pubmed-author:KimlerBruce FBF,
pubmed-author:OstranderJulieJ,
pubmed-author:PaisieCarolynC,
pubmed-author:PiliePatrick GPG,
pubmed-author:ReynoldsPaul APA,
pubmed-author:ScottVictoriaV,
pubmed-author:SeewaldtVictoria LVL,
pubmed-author:TlstyThea DTD,
pubmed-author:WilkeLee GLG,
pubmed-author:YeeLisaL,
pubmed-author:ZallesCarola MCM
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pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
6834-41
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18006786-Adult,
pubmed-meshheading:18006786-Aged,
pubmed-meshheading:18006786-Breast Neoplasms,
pubmed-meshheading:18006786-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:18006786-DNA Methylation,
pubmed-meshheading:18006786-Epithelial Cells,
pubmed-meshheading:18006786-Female,
pubmed-meshheading:18006786-Gene Silencing,
pubmed-meshheading:18006786-Humans,
pubmed-meshheading:18006786-Mammary Glands, Human,
pubmed-meshheading:18006786-Middle Aged,
pubmed-meshheading:18006786-Promoter Regions, Genetic,
pubmed-meshheading:18006786-Risk
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pubmed:year |
2007
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pubmed:articleTitle |
Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF.
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pubmed:affiliation |
Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|