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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22 Pt 1
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
The mechanism of sensitivity and resistance to epidermal growth factor receptor (EGFR) inhibitors is incompletely understood, particularly in cancers other than non-small-cell lung cancer (NSCLC). To understand the variable response to this class of drugs, we used the NCI60 cancer cell lines. We aimed to determine if there are interactions between EGFR expression, mutations, polymorphisms, and gene amplification, and whether these factors are associated with variability in response to EGFR inhibitors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BatesSusan ESE,
pubmed-author:CookEdwin HEHJr,
pubmed-author:CoxNancy JNJ,
pubmed-author:DasSomaS,
pubmed-author:FackenthalDonna LeeDL,
pubmed-author:HuffLyn MickleyLM,
pubmed-author:InnocentiFedericoF,
pubmed-author:LiuWanqingW,
pubmed-author:MontenegroRaquel CRC,
pubmed-author:RatainMark JMJ,
pubmed-author:SpitzJared AJA,
pubmed-author:WuXiaolinX,
pubmed-author:ZhangWeiW
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6788-95
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18006781-Cell Line, Tumor,
pubmed-meshheading:18006781-Drug Resistance, Neoplasm,
pubmed-meshheading:18006781-Gene Amplification,
pubmed-meshheading:18006781-Humans,
pubmed-meshheading:18006781-Linkage Disequilibrium,
pubmed-meshheading:18006781-Mutation,
pubmed-meshheading:18006781-Polymorphism, Genetic,
pubmed-meshheading:18006781-Protein Kinase Inhibitors,
pubmed-meshheading:18006781-Protein Structure, Tertiary,
pubmed-meshheading:18006781-Protein-Tyrosine Kinases,
pubmed-meshheading:18006781-Receptor, Epidermal Growth Factor
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pubmed:year |
2007
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pubmed:articleTitle |
Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines.
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pubmed:affiliation |
Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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