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pubmed-article:18006759pubmed:abstractTextIn many childhood neoplasms, prognostic subgroups have been defined based on specific chromosome changes. In Wilms' tumor (WT), such subclassification has been hampered by the diverse and relatively unspecific pattern of chromosomal imbalances present in these tumors. Unspecific patterns of cytogenetic imbalances in tumors are often caused by mitotic segregation errors due to short dysfunctional telomeres. As an alternative to cytogenetic classification, we therefore have evaluated whether the rate of telomere-dependent chromosomal instability could influence the clinical course in WT patients.lld:pubmed
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pubmed-article:18006759pubmed:articleTitleDefective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors.lld:pubmed
pubmed-article:18006759pubmed:affiliationDepartment of Clinical Genetics, Lund University Hospital, Lund, Sweden. ylva.stewenius@med.lu.selld:pubmed
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pubmed-article:18006759pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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