Linked Life Data

18006759

Source:http://linkedlifedata.com/resource/pubmed/id/18006759

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22 Pt 1
pubmed:dateCreated
2007-11-16
pubmed:abstractText
In many childhood neoplasms, prognostic subgroups have been defined based on specific chromosome changes. In Wilms' tumor (WT), such subclassification has been hampered by the diverse and relatively unspecific pattern of chromosomal imbalances present in these tumors. Unspecific patterns of cytogenetic imbalances in tumors are often caused by mitotic segregation errors due to short dysfunctional telomeres. As an alternative to cytogenetic classification, we therefore have evaluated whether the rate of telomere-dependent chromosomal instability could influence the clinical course in WT patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6593-602
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Defective chromosome segregation and telomere dysfunction in aggressive Wilms' tumors.
pubmed:affiliation
Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. ylva.stewenius@med.lu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't