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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-1-30
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pubmed:abstractText |
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in the pathogenesis of cardiovascular diseases via regulating the metabolism and transport of cholesterol. We and others have recently shown that FXR is also expressed in the vasculature, including endothelial cells and smooth muscle cells (SMC). However, the biological significance of FXR activation in SMC is still poorly understood. In this study, we examine the effect of FXR ligands on the angiotensin system in rat aortic SMC (RASMC), as angiotensin II (Ang II) signalling contributes to various types of vascular lesions by promoting cell growth of vascular SMC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Chenodeoxycholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/GW 4064,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Tyrosine Phosphatase...,
http://linkedlifedata.com/resource/pubmed/chemical/Ptpn6 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Angiotensin, Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/farnesoid X-activated receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
560-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18006431-Angiotensin II,
pubmed-meshheading:18006431-Animals,
pubmed-meshheading:18006431-Cells, Cultured,
pubmed-meshheading:18006431-Chenodeoxycholic Acid,
pubmed-meshheading:18006431-DNA-Binding Proteins,
pubmed-meshheading:18006431-Enzyme Activation,
pubmed-meshheading:18006431-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:18006431-Gene Expression Regulation,
pubmed-meshheading:18006431-Isoxazoles,
pubmed-meshheading:18006431-Muscle, Smooth, Vascular,
pubmed-meshheading:18006431-Myocytes, Smooth Muscle,
pubmed-meshheading:18006431-Promoter Regions, Genetic,
pubmed-meshheading:18006431-Protein Tyrosine Phosphatase, Non-Receptor Type 6,
pubmed-meshheading:18006431-Rats,
pubmed-meshheading:18006431-Rats, Sprague-Dawley,
pubmed-meshheading:18006431-Receptor, Angiotensin, Type 2,
pubmed-meshheading:18006431-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:18006431-Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.
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pubmed:affiliation |
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, 639 Salk Hall, Pittsburgh, PA 15261, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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