Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-2-15
pubmed:abstractText
The herpes simplex virus 2 dl5-29 replication-defective mutant virus has been shown to induce protective immunity in mice and both prophylactic and therapeutic immunity in guinea pigs. In an attempt to improve the efficacy of dl5-29 we disrupted its U(L)41 gene, producing the triple mutant virus dl5-29-41L. dl5-29-41L has a decreased ability to inhibit host cell protein synthesis and a reduced cytopathic effect on cultured cells. When used to immunize mice, dl5-29-41L elicited significantly stronger neutralizing antibody responses and significantly stronger CD4(+) and CD8(+) cellular immune responses than dl5-29. The enhanced immune responses corresponded with increased protective capacity in a murine model of genital herpes. The protective immunity elicited by either virus was very durable, protecting mice for at least 7 months. Furthermore, we show that cell lysate preparations of both viruses were significantly more efficacious than the corresponding extracellular virus preparations.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10359827, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10432030, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10438852, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10623769, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10790421, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-10933704, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-11070010, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-11152492, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-11602757, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-11756980, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12242445, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12388816, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12444179, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12447756, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12525427, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12610151, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12721931, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-12915549, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-14512561, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-14614374, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-15063125, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-15596834, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-15699155, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-15914842, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16051826, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16106447, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16118915, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16327322, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16364753, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16762332, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16912297, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-16926356, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-17314338, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-1849612, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-219262, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-4300104, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-6296440, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-7474089, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-7571418, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-8665865, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9185583, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9311788, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9434723, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9525993, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9527927, http://linkedlifedata.com/resource/pubmed/commentcorrection/18006033-9607001
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
372
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
165-75
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
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