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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-1-29
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pubmed:abstractText |
Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The non-synonymous SNPs (nsSNPs) that lead to amino acid changes in the protein product may account for nearly half of the known genetic variations linked to inherited human diseases. One of the key problems of medical genetics today is to identify nsSNPs that underlie disease-related phenotypes in humans. As such, the development of computational tools that can identify such nsSNPs would enhance our understanding of genetic diseases and help predict the disease.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18005451-10592278,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2105
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
450
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18005451-Algorithms,
pubmed-meshheading:18005451-Artificial Intelligence,
pubmed-meshheading:18005451-Base Sequence,
pubmed-meshheading:18005451-DNA Mutational Analysis,
pubmed-meshheading:18005451-Genetic Variation,
pubmed-meshheading:18005451-Humans,
pubmed-meshheading:18005451-Molecular Sequence Data,
pubmed-meshheading:18005451-Pattern Recognition, Automated,
pubmed-meshheading:18005451-Phenotype,
pubmed-meshheading:18005451-Polymorphism, Single Nucleotide,
pubmed-meshheading:18005451-Sequence Alignment,
pubmed-meshheading:18005451-Sequence Analysis, DNA
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pubmed:year |
2007
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pubmed:articleTitle |
Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines.
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pubmed:affiliation |
Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China. tianjian3721@163.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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