|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0001271,
umls-concept:C0017262,
umls-concept:C0026769,
umls-concept:C0026845,
umls-concept:C0035647,
umls-concept:C0035820,
umls-concept:C0068575,
umls-concept:C0185117,
umls-concept:C0220905,
umls-concept:C0221198,
umls-concept:C0333735,
umls-concept:C1515406,
umls-concept:C1704256,
umls-concept:C2911684
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|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2008-10-10
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|
pubmed:abstractText |
Rapid and extensive activation of astrocytes occurs subsequent to many forms of central nervous system (CNS) injury. Recent studies have revealed that the expression profile of reactive astrocytes comprises antigens present during astrocyte development. Elevated levels of the injury-related cytokine transforming growth factor-beta 1 (TGF-beta1) secreted by microglial cells and invading macrophages have been correlated with the reactive astrocyte phenotype and glial scar formation.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
|
pubmed:issn |
1365-2990
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pubmed:author |
|
|
pubmed:issnType |
Electronic
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pubmed:volume |
34
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
532-46
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pubmed:meshHeading |
pubmed-meshheading:18005096-Actins,
pubmed-meshheading:18005096-Adult,
pubmed-meshheading:18005096-Aged,
pubmed-meshheading:18005096-Aged, 80 and over,
pubmed-meshheading:18005096-Animals,
pubmed-meshheading:18005096-Astrocytes,
pubmed-meshheading:18005096-Blotting, Western,
pubmed-meshheading:18005096-Female,
pubmed-meshheading:18005096-Gene Expression,
pubmed-meshheading:18005096-Gene Expression Profiling,
pubmed-meshheading:18005096-Humans,
pubmed-meshheading:18005096-Immunohistochemistry,
pubmed-meshheading:18005096-Intermediate Filament Proteins,
pubmed-meshheading:18005096-Male,
pubmed-meshheading:18005096-Middle Aged,
pubmed-meshheading:18005096-Multiple Sclerosis,
pubmed-meshheading:18005096-Muscle, Smooth,
pubmed-meshheading:18005096-Nerve Tissue Proteins,
pubmed-meshheading:18005096-Rats,
pubmed-meshheading:18005096-Rats, Wistar,
pubmed-meshheading:18005096-Transforming Growth Factor beta1
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Alpha-smooth muscle actin (alpha-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-beta1).
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|
pubmed:affiliation |
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, B-3590 Diepenbeek, Belgium. marjan.moreels@uhasselt.be
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
