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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-7-28
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pubmed:abstractText |
Leukocyte extravasation exacerbates tissue injury after ischaemic stroke. Vascular adhesion protein-1 (VAP-1) is an endothelial adhesion molecule with the potential capacity to guide transmigration of inflammatory cells into ischaemic brain. Moreover, VAP-1 could worsen ischaemic brain injury due to its function as a semicarbazide-sensitive amine oxidase (SSAO) producing toxic metabolites from primary amines. The purpose of this study was to elucidate these aspects of VAP-1-function in the pathogenesis of human ischaemic stroke.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1365-2990
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
394-402
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pubmed:meshHeading |
pubmed-meshheading:18005095-Adult,
pubmed-meshheading:18005095-Aged,
pubmed-meshheading:18005095-Aged, 80 and over,
pubmed-meshheading:18005095-Amine Oxidase (Copper-Containing),
pubmed-meshheading:18005095-Autopsy,
pubmed-meshheading:18005095-Brain Ischemia,
pubmed-meshheading:18005095-Cell Adhesion Molecules,
pubmed-meshheading:18005095-Humans,
pubmed-meshheading:18005095-Immunohistochemistry,
pubmed-meshheading:18005095-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18005095-Middle Aged,
pubmed-meshheading:18005095-Middle Cerebral Artery,
pubmed-meshheading:18005095-Reference Values,
pubmed-meshheading:18005095-Sialoglycoproteins,
pubmed-meshheading:18005095-Stroke,
pubmed-meshheading:18005095-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2008
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pubmed:articleTitle |
Vascular adhesion protein-1 in human ischaemic stroke.
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pubmed:affiliation |
Department of Neurology, MediCity Research Laboratory, Turku University, Turku, Finland. laura.airas@utu.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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