Linked Life Data

18003949

Source:http://linkedlifedata.com/resource/pubmed/id/18003949

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-27
pubmed:abstractText
Parturition does not occur in transgenic mice lacking the prostaglandin F receptor (Ptgfr(-/-)) because luteolysis is forestalled and progesterone production persists. Ovariectomy of pregnant Ptgfr(-/-) mice leads to a decline in circulating progesterone and delivery of live pups. The objective of the present study was to test the hypothesis that immigration of macrophages and increased innervation of the cervix of Ptgfr(-/-) mice was associated with ripening and parturition. The cervix of pregnant Ptgfr(-/-) mice was studied on Days 15-21 after breeding; additional groups were ovariectomized on Day 19 of pregnancy, and the cervix obtained on Day 20 of pregnancy before birth or the next day at about 24 h after birth. On Days 18-19 of pregnancy, macrophage numbers and nerve fiber density increased more than 3-fold compared with findings in nonpregnant or Day 15 or 21 pregnant Ptgfr(-/-) mice. The magnitude and time course of these changes were comparable to those found in wild-type controls that delivered on Day 19 after breeding. Thus, the mechanism regulating macrophage immigration, innervation, and cervical remodeling in Ptgfr(-/-) mice with delayed parturition is similar to wild-type controls that deliver at term. By contrast, ovariectomy forestalled the decrease in cervical macrophages in Ptgfr(-/-) mice. By Day 21 after breeding, macrophage numbers more than double those after ovariectomy, relative to those found in pregnant Ptgfr(-/-) mice, whereas nerve fiber density was the same regardless of birth. Density of collagen structure in these mice directly matched macrophage traffic in the cervix. The findings indicate that the prostaglandin F(2alpha) receptor and progesterone withdrawal are a necessary part of the final common pathway for ripening of the cervix and the process of parturition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
438-44
pubmed:meshHeading
pubmed-meshheading:18003949-Animals, pubmed-meshheading:18003949-Animals, Newborn, pubmed-meshheading:18003949-Cell Movement, pubmed-meshheading:18003949-Cervical Ripening, pubmed-meshheading:18003949-Cervix Uteri, pubmed-meshheading:18003949-Female, pubmed-meshheading:18003949-Gestational Age, pubmed-meshheading:18003949-Intermediate Filament Proteins, pubmed-meshheading:18003949-Macrophages, pubmed-meshheading:18003949-Membrane Glycoproteins, pubmed-meshheading:18003949-Mice, pubmed-meshheading:18003949-Mice, Inbred C57BL, pubmed-meshheading:18003949-Mice, Knockout, pubmed-meshheading:18003949-Nerve Fibers, pubmed-meshheading:18003949-Nerve Tissue Proteins, pubmed-meshheading:18003949-Parturition, pubmed-meshheading:18003949-Pregnancy, pubmed-meshheading:18003949-Pregnancy, Animal, pubmed-meshheading:18003949-Progesterone, pubmed-meshheading:18003949-Receptors, Prostaglandin
pubmed:year
2008
pubmed:articleTitle
Parturition and recruitment of macrophages in cervix of mice lacking the prostaglandin F receptor.
pubmed:affiliation
Department of Physiology, Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. syellon@LLU.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't