Linked Life Data

18003554

Source:http://linkedlifedata.com/resource/pubmed/id/18003554

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-11-16
pubmed:abstractText
The effects of subthalamic nucleus (STN) stimulation and L-dopa administration on the arm and leg swing movements associated with overground walking were studied in a group of patients with idiopathic Parkinson's disease (PD). Ten patients undergoing deep brain stimulation and twenty controls were tested using 3D kinematic motion analysis. Parkinsonian patients under basal conditions walked more slowly and with reduced arm and leg swing compared to controls. Moreover, they displayed significant impairments of the normal interlimb coordination. Both STN stimulation and L-dopa increased the walking speed and the amplitude of arm and leg swing movements. Additional improvements of the coordination between upper and lower limb were documented by reductions of the phase-shift between arm and ipsilateral leg motion, with displacement toward the control range (perfect counterphase). STN stimulation alone and L-dopa alone produced similar effects on the variables analyzed. The combination of the two treatments, instead, yielded additive effects on the gait speed and a slight increase of the upper and lower limb range of motion, in the absence of further improvements in the inter-segmental coordination. Moreover, whereas the increased arm swing could be accounted by the sole adoption of a higher gait speed, both the increment of the leg movement amplitude and the decreased interlimb phase shift appeared to imply an additional effect, possibly related to the treatment. These results may suggest that differential supraspinal controls operate on the neural networks subserving upper and lower limb motion during human walking.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-170X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2007
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6665-8
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Effect of L-dopa and subthalamic nucleus stimulation on arm and leg swing during gait in Parkinson's Disease.
pubmed:affiliation
Bioengineering Centre, Don Carlo Gnocchi Foundation Onlus IRCCS, Milan, Italy. icarpinella@dongnocchi.it
pubmed:publicationType
Journal Article, Controlled Clinical Trial, Research Support, Non-U.S. Gov't