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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1992-4-21
|
| pubmed:abstractText |
We examined the release of endothelin from cultured epithelial cells of guinea-pig trachea in response to treatment with endotoxin, using a sandwich-enzyme immunoassay. Cultured epithelial cells released endothelin in a time-dependent fashion (3, 6, 12, 24 h), and endotoxin (4-40 micrograms/ml) significantly increased endothelin release. Endotoxin (4-10 micrograms/ml) showed no cytotoxicity against epithelial cells. These results suggest that guinea-pig airway epithelial cells are capable of producing endothelin and this peptide may be related to the pathophysiological effects of endotoxin.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
203
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
299-302
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1800122-Animals,
pubmed-meshheading:1800122-Cells, Cultured,
pubmed-meshheading:1800122-Endothelins,
pubmed-meshheading:1800122-Endotoxins,
pubmed-meshheading:1800122-Epithelial Cells,
pubmed-meshheading:1800122-Epithelium,
pubmed-meshheading:1800122-Guinea Pigs,
pubmed-meshheading:1800122-Stimulation, Chemical,
pubmed-meshheading:1800122-Trachea
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Endotoxin stimulates endothelin release from cultured epithelial cells of guinea-pig trachea.
|
| pubmed:affiliation |
Division of Pulmonary Medicine, University of Tsukuba, Ibaraki, Japan.
|
| pubmed:publicationType |
Journal Article
|