Source:http://linkedlifedata.com/resource/pubmed/id/18000313
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2007-11-16
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| pubmed:abstractText |
Growth and sexual development are closely interlinked in fish; however, no reports exist on potential effects of estrogen on the GH/IGF-I-axis in developing fish. We investigate whether estrogen exposure during early development affects growth and the IGF-I system, both at the systemic and tissue level. Tilapia were fed from 10 to 40 days post fertilization (DPF) with 17alpha-ethinylestradiol (EE(2)). At 50, 75, 90, and 165 DPF, length, weight, sex ratio, serum IGF-I (RIA), pituitary GH mRNA and IGF-I, and estrogen receptor alpha (ERalpha) mRNA in liver, gonads, brain, and gills (real-time PCR) were determined and the results correlated to those of in situ hybridization for IGF-I. Developmental exposure to EE(2) had persistent effects on sex ratio and growth. Serum IGF-I, hepatic IGF-I mRNA, and the number of IGF-I mRNA-containing hepatocytes were significantly decreased at 75 DPF, while liver ERalpha mRNA was significantly induced. At 75 DPF, a transient decline of IGF-I mRNA and a largely reduced number of IGF-I mRNA-containing neurons were observed in the female brain. In both sexes, pituitary GH mRNA was significantly suppressed. A transient downregulation of IGF-I mRNA occurred in ovaries (75 DPF) and testes (90 DPF). In agreement, in situ hybridization revealed less IGF-I mRNA signals in granulosa and germ cells. Our results show for the first time that developmental estrogen treatment impairs GH/IGF-I expression in fish, and that the effects persist. These long-lasting effects both seem to be exerted indirectly via inhibition of pituitary GH and directly by suppression of local IGF-I in organ-specific cells.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Receptor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1479-6805
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
195
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
513-23
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| pubmed:meshHeading |
pubmed-meshheading:18000313-Aging,
pubmed-meshheading:18000313-Animals,
pubmed-meshheading:18000313-Body Size,
pubmed-meshheading:18000313-Body Weight,
pubmed-meshheading:18000313-Brain,
pubmed-meshheading:18000313-Estrogen Receptor alpha,
pubmed-meshheading:18000313-Ethinyl Estradiol,
pubmed-meshheading:18000313-Female,
pubmed-meshheading:18000313-Gills,
pubmed-meshheading:18000313-Growth Hormone,
pubmed-meshheading:18000313-In Situ Hybridization,
pubmed-meshheading:18000313-Insulin-Like Growth Factor I,
pubmed-meshheading:18000313-Liver,
pubmed-meshheading:18000313-Male,
pubmed-meshheading:18000313-Ovary,
pubmed-meshheading:18000313-Pituitary Gland,
pubmed-meshheading:18000313-RNA, Messenger,
pubmed-meshheading:18000313-Sex Ratio,
pubmed-meshheading:18000313-Testis,
pubmed-meshheading:18000313-Tilapia
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| pubmed:year |
2007
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| pubmed:articleTitle |
Ethinylestradiol differentially interferes with IGF-I in liver and extrahepatic sites during development of male and female bony fish.
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| pubmed:affiliation |
Division of Neuroendocrinology, Institute of Anatomy, University of Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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