Linked Life Data

18000230

Source:http://linkedlifedata.com/resource/pubmed/id/18000230

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-11-16
pubmed:abstractText
Using intact villous fragments from normal term placentas, the authors characterize the effect of reduced amino acid availability on amino acid uptake via the system A amino acid transporter. Villous fragments deprived of amino acids demonstrate increased system A activity compared with those incubated in an amino acid-sufficient medium (P < .05). Similarly, placental villous fragments exposed to media containing only amino acids not specifically transported by system A have a significant increase in system A activity compared with villous fragments incubated in an amino acid-sufficient medium containing only substrates of system A (P < .05). There is a significant trend for increasing system A activity as the concentrations of the system A amino acid substrates are decreased (P < .01). Collectively, these data indicate that normal placentas can increase system A amino acid transporter activity in a substrate-specific and dose-dependent manner as a means to ensure optimal fetal growth in the presence of amino acid limitation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1933-7205
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
687-93
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
System A amino acid transporter activity in term placenta is substrate specific and inversely related to amino acid concentration.
pubmed:affiliation
Magee-Womens Research Institute, Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylania 15213, USA. parrott.meredith@medstudent.pitt.edu
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural