Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
47
pubmed:dateCreated
2007-11-27
pubmed:abstractText
Accurate and efficient splicing of eukaryotic pre-mRNAs requires recognition by trans-acting factors of a complex array of cis-acting RNA elements. Here, we developed a generalized Bayesian network to model the coevolution of splicing cis elements in diverse eukaryotic taxa. Cross-exon but not cross-intron compensatory interactions between the 5' splice site (5'ss) and 3' splice site (3'ss) were observed in human/mouse, indicating that the exon is the primary evolutionary unit in mammals. Studied plants, fungi, and invertebrates exhibited exclusively cross-intron interactions, suggesting that intron definition drives evolution in these organisms. In mammals, 5'ss strength and the strength of several classes of exonic splicing silencers (ESSs) evolved in a correlated way, whereas specific exonic splicing enhancers (ESEs), including motifs associated with hTra2, SRp55, and SRp20, evolved in a compensatory manner relative to the 5'ss and 3'ss. Interactions between specific ESS or ESE motifs were not observed, suggesting that elements bound by different factors are not commonly interchangeable. Thus, the splicing elements defining exons coevolve in a way that preserves overall exon strength, allowing specific elements to substitute for loss or weakening of others.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-10022858, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-10395560, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-10694877, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11046128, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11108481, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11572975, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11779509, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11893484, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-11967553, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-12114529, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-12519945, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-12600935, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-12626338, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15168696, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15272122, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15285897, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-1531115, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15340491, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15470237, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15505203, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15607979, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15845847, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15956978, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-15989965, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16260721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16381932, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16632598, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16651655, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16766678, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16797197, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16818600, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-16855287, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-17121466, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-17156453, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-2136768, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-7585252, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-7852296, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-8164690, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-8336736, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-8986767, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-8989884, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-9234714, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-9546399, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-9649504, http://linkedlifedata.com/resource/pubmed/commentcorrection/17998536-9742110
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1091-6490
pubmed:author
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18583-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Coevolutionary networks of splicing cis-regulatory elements.
pubmed:affiliation
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural