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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Many previous studies have investigated whether there is an association between genotypes at the angiotensinogen (AGT) gene and hypertensive status, but few have incorporated quantitative data. Although meta-analyses support a possible effect of AGT variants on blood pressure (BP), substantial unexplained between-study heterogeneity has been observed. We hypothesized that a primary effect of AGT variants on arterial stiffness (and thus pulse pressure) might explain such heterogeneity, and tested for such an effect in a family study.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0300-5771
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1356-62
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17998241-Adult,
pubmed-meshheading:17998241-Alleles,
pubmed-meshheading:17998241-Angiotensinogen,
pubmed-meshheading:17998241-Antihypertensive Agents,
pubmed-meshheading:17998241-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:17998241-Cohort Studies,
pubmed-meshheading:17998241-Confounding Factors (Epidemiology),
pubmed-meshheading:17998241-Female,
pubmed-meshheading:17998241-Genetic Predisposition to Disease,
pubmed-meshheading:17998241-Genetic Variation,
pubmed-meshheading:17998241-Genotype,
pubmed-meshheading:17998241-Humans,
pubmed-meshheading:17998241-Hypertension,
pubmed-meshheading:17998241-Male,
pubmed-meshheading:17998241-Middle Aged,
pubmed-meshheading:17998241-Polymorphism, Genetic,
pubmed-meshheading:17998241-Pulse,
pubmed-meshheading:17998241-Regression Analysis
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pubmed:year |
2007
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pubmed:articleTitle |
The C-532T polymorphism of the angiotensinogen gene is associated with pulse pressure: a possible explanation for heterogeneity in genetic association studies of AGT and hypertension.
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pubmed:affiliation |
The Institute of Human Genetics, Newcastle University, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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