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rdf:type |
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lifeskim:mentions |
umls-concept:C0179400,
umls-concept:C0243125,
umls-concept:C0299250,
umls-concept:C0678594,
umls-concept:C0699900,
umls-concept:C0719053,
umls-concept:C1332762,
umls-concept:C1414313,
umls-concept:C1708533,
umls-concept:C1853126,
umls-concept:C2698172
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pubmed:issue |
11
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pubmed:dateCreated |
2007-11-13
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pubmed:databankReference |
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pubmed:abstractText |
Tyrosine kinase signaling is tightly controlled by negative feedback inhibitors including suppressors of cytokine signaling (SOCS). SOCS assemble as SH2 domain substrate recognition modules in ElonginB/C-cullin ubiquitin ligases. In accordance, SOCS4 reduces STAT3 signaling from EGFR through increased receptor degradation. Variable C-termini in SOCS4-SOCS7 exclude these family members from a SOCS2-type domain arrangement in which a strictly conserved C terminus determines domain packing. The structure of the SOCS4-ElonginC-ElonginB complex reveals a distinct SOCS structural class. The N-terminal ESS helix functionally replaces the CIS/SOCS1-SOCS3 family C terminus in a distinct SH2-SOCS box interface that facilitates further interdomain packing between the extended N- and C-terminal regions characteristic for this subfamily. Using peptide arrays and calorimetry the STAT3 site in EGFR (pY(1092)) was identified as a high affinity SOCS4 substrate (K(D) = 0.5 microM) revealing a mechanism for EGFR degradation. SOCS4 also bound JAK2 and KIT with low micromolar affinity, whereas SOCS2 was specific for GH-receptor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-10064597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-10078535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-10205047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-10222271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-11290583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-11961546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12052866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12070153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12076535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12101419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12119038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12228220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12239347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12242343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12411582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-12591923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-14679191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-14707129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-14764607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-14993666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15488148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15572765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15590694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15601820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15688063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15690087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15695332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15780933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-15930003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16122940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16273093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16630890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16675548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16794031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16829981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-16905102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-17208301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-17404288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-17434132,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-17463226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-2236073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-7521735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-7527391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-7566171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-7680959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-8578591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-8940013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9202125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9419338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9489922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9630226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9789053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9869640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17997974-9889194
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/EGFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Isoleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/SOCS4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor of Cytokine Signaling...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/elongin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1493-504
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pubmed:dateRevised |
2009-11-19
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