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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2008-2-22
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pubmed:abstractText |
Expansions of triplet repeats are found in a number of neurodegenerative conditions, and different tissues in the same person can have varying repeat lengths. In Kennedy disease, motor neuron loss is due to expansion of the CAG repeat length in the androgen receptor gene (AR). We hypothesised that patients with other sporadic motor neuron diseases could have AR expansions that were restricted to CNS tissue.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-510X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
267
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17997416-Adult,
pubmed-meshheading:17997416-Age of Onset,
pubmed-meshheading:17997416-Aged,
pubmed-meshheading:17997416-Aged, 80 and over,
pubmed-meshheading:17997416-Brain,
pubmed-meshheading:17997416-Cell Death,
pubmed-meshheading:17997416-DNA Mutational Analysis,
pubmed-meshheading:17997416-Disease Progression,
pubmed-meshheading:17997416-Female,
pubmed-meshheading:17997416-Genetic Markers,
pubmed-meshheading:17997416-Genetic Predisposition to Disease,
pubmed-meshheading:17997416-Genetic Testing,
pubmed-meshheading:17997416-Humans,
pubmed-meshheading:17997416-Male,
pubmed-meshheading:17997416-Middle Aged,
pubmed-meshheading:17997416-Motor Neuron Disease,
pubmed-meshheading:17997416-Mutation,
pubmed-meshheading:17997416-Nerve Degeneration,
pubmed-meshheading:17997416-Receptors, Androgen,
pubmed-meshheading:17997416-Trinucleotide Repeat Expansion
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pubmed:year |
2008
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pubmed:articleTitle |
A comparison of the lengths of androgen receptor triplet repeats in brain and blood in motor neuron diseases.
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pubmed:affiliation |
Department of Pathology, The University of Sydney, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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