Linked Life Data

17997077

Source:http://linkedlifedata.com/resource/pubmed/id/17997077

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-3-24
pubmed:abstractText
Transcriptional analysis of Salmonella enterica serovar Typhimurium (S. Typhimurium) in the presence of the mammalian hormone norepinephrine revealed up-regulation of genes in the flagellar and chemotaxis regulon. Motility assays confirmed enhanced motility of wild-type S. Typhimurium in the presence of norepinephrine that could be blocked by the alpha-adrenergic antagonist, phentolamine. Furthermore, a mutation in the qseC gene, encoding the sensor kinase of the two-component QseBC quorum-sensing system, also diminished motility of S. Typhimurium. To investigate the role of S. Typhimurium QseC in vivo, 13-week old pigs were intranasally inoculated with equal concentrations (1 x 10(9)CFU) of wild-type S. Typhimurium and a qseC mutant. Over a 1-week competitive index experiment, the qseC mutant displayed decreased colonization of the gastrointestinal tract compared to the wild-type parent strain. Thus, this study has identified a role for the QseBC quorum-sensing signal transduction system in motility and swine colonization of S. Typhimurium. Cross-talk between cell-cell communication systems in Salmonella (quorum sensing) and host hormones may explain opportunistic behaviors of the pathogen, such as immune evasion and stress-induced recrudescence of Salmonella, during fluctuations of host hormone levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0882-4010
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
271-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of the QseC quorum-sensing sensor kinase in colonization and norepinephrine-enhanced motility of Salmonella enterica serovar Typhimurium.
pubmed:affiliation
Swine Odor and Manure Management Research Unit, USDA, ARS, National Soil Tilth Laboratory, Ames, IA 50011, USA. brad.bearson@ars.usda.gov
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.