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rdf:type |
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lifeskim:mentions |
umls-concept:C0021270,
umls-concept:C0025260,
umls-concept:C0205195,
umls-concept:C0205263,
umls-concept:C0205314,
umls-concept:C0206515,
umls-concept:C0301869,
umls-concept:C0358314,
umls-concept:C0439662,
umls-concept:C0679622,
umls-concept:C0872192,
umls-concept:C1977484,
umls-concept:C1979924
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pubmed:issue |
51
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pubmed:dateCreated |
2007-12-10
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pubmed:databankReference |
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pubmed:abstractText |
Immunogenicity and safety of a novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine (Hib-MenCY-TT) candidate was evaluated when co-administered with DTPa-HBV-IPV(Pediarix)+PCV7(Prevnar) at 2-4-6 months of age. Anti-PRP concentrations >or= 1.0 microg/mL were observed in 92.9-98.7%, rSBA-MenC/Y titres >or= 1:8 in >98%, rSBA-MenC/Y titres >or= 1:128 in >95.8 and >89.9% subjects. PRP and MenC responses were similar to respective controls (ActHIB and Menjugate) including for antibody persistence. Response to co-administered vaccines was not impaired. Polysaccharide challenge (PRP, PSC, PSY at 11-14 months of age) evidenced immune memory was induced for Hib, MenC/Y conjugate components. The safety profile of Hib-MenCY-TT was similar to controls. Hib-MenCY-TT administered according to the current US Hib vaccine schedule has the potential to induce protective antibodies against Hib and meningococcal-CY disease in infants and toddlers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Complement System Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DTPa-HBV-IPV combined vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Diphtheria-Tetanus-Pertussis Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Haemophilus Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Poliovirus Vaccine, Inactivated,
http://linkedlifedata.com/resource/pubmed/chemical/Tetanus Toxoid,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Combined,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Conjugate
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8487-99
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17996996-Antibodies, Bacterial,
pubmed-meshheading:17996996-Bacterial Vaccines,
pubmed-meshheading:17996996-Blood Bactericidal Activity,
pubmed-meshheading:17996996-Complement System Proteins,
pubmed-meshheading:17996996-Diphtheria-Tetanus-Pertussis Vaccine,
pubmed-meshheading:17996996-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17996996-Female,
pubmed-meshheading:17996996-Haemophilus Vaccines,
pubmed-meshheading:17996996-Haemophilus influenzae type b,
pubmed-meshheading:17996996-Hepatitis B Vaccines,
pubmed-meshheading:17996996-Humans,
pubmed-meshheading:17996996-Immunologic Memory,
pubmed-meshheading:17996996-Infant,
pubmed-meshheading:17996996-Male,
pubmed-meshheading:17996996-Neisseria meningitidis, Serogroup C,
pubmed-meshheading:17996996-Neisseria meningitidis, Serogroup Y,
pubmed-meshheading:17996996-Poliovirus Vaccine, Inactivated,
pubmed-meshheading:17996996-Tetanus Toxoid,
pubmed-meshheading:17996996-Vaccines, Combined,
pubmed-meshheading:17996996-Vaccines, Conjugate
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pubmed:year |
2007
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pubmed:articleTitle |
A novel combined Haemophilus influenzae type b-Neisseria meningitidis serogroups C and Y-tetanus-toxoid conjugate vaccine is immunogenic and induces immune memory when co-administered with DTPa-HBV-IPV and conjugate pneumococcal vaccines in infants.
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pubmed:affiliation |
Murdoch Children's Research Institute and School of Population Health, The University of Melbourne, Australia. t.nolan@unimelb.edu.au
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
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