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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-2-4
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621726,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621727,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621728,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621729,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621730,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621731,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621732,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621733,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621734,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621735,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621736,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621737,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621738,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621739,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621740,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621741,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621742,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621743,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621744,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621745,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621746,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621747,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621748,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621749,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621750,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621751,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621752,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/EF621753
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pubmed:abstractText |
Influenza B viruses were predominant in Taiwan during the 2004-2005 epidemic and both Victoria and Yamagata lineage viruses co-circulated. A reassortant influenza B virus that contained a Victoria lineage hemagglutinin (HA) gene and Yamagata lineage neuraminidase (NA) gene appeared first in 2002 and became predominant during the 2004-2005 epidemic. During the 2006-2007 epidemic, an influenza B outbreak occurred in Taiwan and only Victoria lineage viruses circulated. We characterized the viruses isolated in the 2006-2007 epidemic and found that the HA genes of influenza B viruses from that epidemic were highly similar to those from the 2004-2005 epidemic. We also analyzed the NA genes of isolates from the 2006-2007 epidemic and found that they all belonged to the Yamagata lineage and formed a new genetic subclade. Comparison of isolates from the 2004-2005 and 2006-2007 epidemics revealed four substitutions, N220K, E320D, K343R and E404K in NA genes. Although the HA sequences from the 2006-2007 epidemic were similar to those from the 2004-2005 epidemic, the NA sequences differed, suggesting distinct patterns of evolution of the HA and NA genes from 2004-2007 in Taiwan. This study emphasizes that the evolution of the NA genes may contribute to reemergence of influenza B viruses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0168-1702
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-9
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pubmed:meshHeading |
pubmed-meshheading:17996973-Amino Acid Substitution,
pubmed-meshheading:17996973-Disease Outbreaks,
pubmed-meshheading:17996973-Evolution, Molecular,
pubmed-meshheading:17996973-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:17996973-Humans,
pubmed-meshheading:17996973-Influenza, Human,
pubmed-meshheading:17996973-Influenza B virus,
pubmed-meshheading:17996973-Molecular Sequence Data,
pubmed-meshheading:17996973-Phylogeny,
pubmed-meshheading:17996973-RNA, Viral,
pubmed-meshheading:17996973-Sequence Analysis, DNA,
pubmed-meshheading:17996973-Sequence Homology, Amino Acid,
pubmed-meshheading:17996973-Taiwan,
pubmed-meshheading:17996973-Viral Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Genetic analysis and evaluation of the reassortment of influenza B viruses isolated in Taiwan during the 2004-2005 and 2006-2007 epidemics.
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pubmed:affiliation |
National Influenza Center, Centers for Disease Control, Taipei, Taiwan, ROC.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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