rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-12-17
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pubmed:abstractText |
Elevated levels of circulating interleukin-6 (IL-6) have been reported in patients with abdominal aortic aneurysms (AAAs). Although this implicates inflammation as a cause of AAAs, there is also evidence that the aneurysmal aorta may secrete IL-6 into the circulation as a result of aortic proteolysis. Genetic association studies are one means of trying to clarify the role of specific mediators in the causal pathway. The aim of the present study was to examine the association between variants of the IL-6 gene and AAAs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1532-2165
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17996468-Aged,
pubmed-meshheading:17996468-Aged, 80 and over,
pubmed-meshheading:17996468-Aortic Aneurysm, Abdominal,
pubmed-meshheading:17996468-Case-Control Studies,
pubmed-meshheading:17996468-Gene Frequency,
pubmed-meshheading:17996468-Genetic Predisposition to Disease,
pubmed-meshheading:17996468-Haplotypes,
pubmed-meshheading:17996468-Humans,
pubmed-meshheading:17996468-Interleukin-6,
pubmed-meshheading:17996468-Male,
pubmed-meshheading:17996468-Multivariate Analysis,
pubmed-meshheading:17996468-Odds Ratio,
pubmed-meshheading:17996468-Polymorphism, Single Nucleotide,
pubmed-meshheading:17996468-Promoter Regions, Genetic,
pubmed-meshheading:17996468-Risk Assessment,
pubmed-meshheading:17996468-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm.
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pubmed:affiliation |
School of Surgery and Pathology, University of Western Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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