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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-12
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pubmed:abstractText |
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Applying in silico tools such as population pharmacokinetic analysis and simulation will help to find adequate dosing strategies and increase the probability of success for a randomized controlled trial. * Up to now, for carvedilol in paediatric patients with congestive heart failure (CHF) the dose has been linearly extrapolated from adults, but the results with this dosing strategy are ambiguous. * Further trials are necessary to establish carvedilol for paediatric patients with CHF.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-10215174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-10356399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-10898112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-10934668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-11041564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-11295713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-11573066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-11999292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-12040358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-12475466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-12523655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-12856383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-13679531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-15001973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-15261177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-15517550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-16353925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-16495250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-16671962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-17301735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-17848651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-1970265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-2454375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-2760818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-3118743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-3428345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-6689647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-8614419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-8654200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-8743333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-9164697,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17995971-9416779
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1365-2125
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-22
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pubmed:dateRevised |
2011-1-11
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pubmed:meshHeading |
pubmed-meshheading:17995971-Adolescent,
pubmed-meshheading:17995971-Adrenergic alpha-Antagonists,
pubmed-meshheading:17995971-Adult,
pubmed-meshheading:17995971-Body Weight,
pubmed-meshheading:17995971-Carbazoles,
pubmed-meshheading:17995971-Child,
pubmed-meshheading:17995971-Child, Preschool,
pubmed-meshheading:17995971-Computer Simulation,
pubmed-meshheading:17995971-Dose-Response Relationship, Drug,
pubmed-meshheading:17995971-Female,
pubmed-meshheading:17995971-Germany,
pubmed-meshheading:17995971-Heart Failure,
pubmed-meshheading:17995971-Humans,
pubmed-meshheading:17995971-Infant,
pubmed-meshheading:17995971-Infant, Newborn,
pubmed-meshheading:17995971-Male,
pubmed-meshheading:17995971-Models, Theoretical,
pubmed-meshheading:17995971-Propanolamines,
pubmed-meshheading:17995971-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure.
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pubmed:affiliation |
Clinical Pharmacology and Pharmacotherapy, University of Düsseldorf, Germany.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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