Linked Life Data

17994796

Source:http://linkedlifedata.com/resource/pubmed/id/17994796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2007-11-12
pubmed:abstractText
Arsenic trioxide (ATO, Trisenox) is a potent anti-vascular agent and significantly enhances hyperthermia and radiation response. To understand the mechanism of the anti-tumor effect in vivo we imaged the binding of a fluorescently-labeled poly-caspase inhibitor (FLIVO) in real time before and 3 h or 24 h after injection of 8 mg/kg ATO. FSaII tumors were grown in dorsal skin-fold window chambers or on the rear limb and we observed substantial poly-caspase binding associated with vascular damage induced by ATO treatment at 3 and 24 h after ATO injection. Flow cytometric analysis of cells dissociated from the imaged tumor confirmed cellular uptake and binding of the FLIVO probe. Apoptosis appears to be a major mode of cell death induced by ATO in the tumor and the use of fluorescently tagged caspase inhibitors to assess cell death in live animals appears feasible to monitor and/or confirm anti-tumor effects of therapy.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-10507779, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-10549607, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-10744422, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-10942603, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-11123277, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-11309811, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-11563754, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-11689890, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-11891718, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-12073450, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-12533214, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-14756449, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-15968678, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-16222122, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-16340727, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-9279777, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-9600968, http://linkedlifedata.com/resource/pubmed/commentcorrection/17994796-9626510
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1533-0346
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
651-4
pubmed:dateRevised
2011-6-17
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy.
pubmed:affiliation
University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. rjgriffin@uams.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural