| pubmed-article:17994021 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17994021 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:17994021 | lifeskim:mentions | umls-concept:C0035681 | lld:lifeskim |
| pubmed-article:17994021 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:17994021 | lifeskim:mentions | umls-concept:C1551084 | lld:lifeskim |
| pubmed-article:17994021 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:17994021 | pubmed:dateCreated | 2007-11-29 | lld:pubmed |
| pubmed-article:17994021 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17994021 | pubmed:abstractText | Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of genes. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto-oncogenes, whose expression is attenuated by regulated stalling of polymerase elongation within the promoter-proximal region. To determine the importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for Drosophila melanogaster genes with Pol II stalled within the promoter-proximal region. Our data show that stalling is widespread, occurring at hundreds of genes that respond to stimuli and developmental signals. This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues. | lld:pubmed |
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| pubmed-article:17994021 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17994021 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17994021 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17994021 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17994021 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17994021 | pubmed:issn | 1546-1718 | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:AdelmanKarenK | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:NechaevSergei... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:ParkerJoel... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:ZeitlingerJul... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:GrissomSherry... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:MuseGinger... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:GilchristDani... | lld:pubmed |
| pubmed-article:17994021 | pubmed:author | pubmed-author:ShahRuchirR | lld:pubmed |
| pubmed-article:17994021 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17994021 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:17994021 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17994021 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17994021 | pubmed:pagination | 1507-11 | lld:pubmed |
| pubmed-article:17994021 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17994021 | pubmed:meshHeading | pubmed-meshheading:17994021... | lld:pubmed |
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| pubmed-article:17994021 | pubmed:meshHeading | pubmed-meshheading:17994021... | lld:pubmed |
| pubmed-article:17994021 | pubmed:meshHeading | pubmed-meshheading:17994021... | lld:pubmed |
| pubmed-article:17994021 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17994021 | pubmed:articleTitle | RNA polymerase is poised for activation across the genome. | lld:pubmed |
| pubmed-article:17994021 | pubmed:affiliation | Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. | lld:pubmed |
| pubmed-article:17994021 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17994021 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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