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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-11-12
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pubmed:abstractText |
The pharmacokinetics and dosage regimen of norfloxacin-glycine acetate (NFLXGA) was investigated in pigs after a single intravenous (i.v.) or oral (p.o.) administration at a dosage of 7.2 mg/kg body weight. After both i.v. and p.o. administration, plasma drug concentrations were best fitted to an open two-compartment model with a rapid distribution phase. After i.v. administration of NFLXGA, the distribution (t(1/2alpha)) and elimination half-life (t(1/2beta)) were 0.36 +/- 0.07 h and 7.42 +/- 3.55 h, respectively. The volume of distribution of NFLXGA at steady state (Vd(ss)) was 4.66 +/- 1.39 l/kg. After p.o. administration of NFLXGA, the maximal absorption concentration (C(max)) was 0.43 +/- 0.06 microg/ ml at 1.36 +/- 0.39 h (T(max)). The mean absorption (t(1/2ka)) and elimination half-life (t(1/2beta)) of NFLXGA were 0.78 +/- 0.27 h and 7.13 +/- 1.41 h, respectively. The mean systemic bioavailability (F) after p.o. administration was 31.10 +/- 15.16%. We suggest that the optimal dosage calculated from the pharmacokinetic parameters is 5.01 mg/kg per day i.v. or 16.12 mg/kg per day p.o.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-10447831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-10678784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-11020298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-11180196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-11555178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-12204627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-12379929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-12507569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-1466505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-2306672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-2389884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-3282749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-6237890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-7629923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-7674459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-7839746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-8735421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-8863267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-8916010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-9597656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17993748-9637308
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1229-845X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-6
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
pubmed-meshheading:17993748-Administration, Oral,
pubmed-meshheading:17993748-Animals,
pubmed-meshheading:17993748-Anti-Bacterial Agents,
pubmed-meshheading:17993748-Biological Availability,
pubmed-meshheading:17993748-Cross-Over Studies,
pubmed-meshheading:17993748-Glycine,
pubmed-meshheading:17993748-Half-Life,
pubmed-meshheading:17993748-Injections, Intravenous,
pubmed-meshheading:17993748-Male,
pubmed-meshheading:17993748-Norfloxacin,
pubmed-meshheading:17993748-Swine,
pubmed-meshheading:17993748-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Clinical pharmacokinetics of norfloxacin-glycine acetate after intravenous and oral administration in pigs.
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pubmed:affiliation |
College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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