|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5852
|
|
pubmed:dateCreated |
2007-11-9
|
|
pubmed:abstractText |
The mammalian target of rapamycin, mTOR, is a central regulator of cell growth. Its activity is regulated by Rheb, a Ras-like small guanosine triphosphatase (GTPase), in response to growth factor stimulation and nutrient availability. We show that Rheb regulates mTOR through FKBP38, a member of the FK506-binding protein (FKBP) family that is structurally related to FKBP12. FKBP38 binds to mTOR and inhibits its activity in a manner similar to that of the FKBP12-rapamycin complex. Rheb interacts directly with FKBP38 and prevents its association with mTOR in a guanosine 5'-triphosphate (GTP)-dependent manner. Our findings suggest that FKBP38 is an endogenous inhibitor of mTOR, whose inhibitory activity is antagonized by Rheb in response to growth factor stimulation and nutrient availability.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media,
http://linkedlifedata.com/resource/pubmed/chemical/FKBP8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Guanosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mutant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RHEB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/mTORC1 complex, human
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
1095-9203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
9
|
|
pubmed:volume |
318
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
977-80
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:17991864-Amino Acids,
pubmed-meshheading:17991864-Cell Line,
pubmed-meshheading:17991864-Culture Media,
pubmed-meshheading:17991864-Guanosine Triphosphate,
pubmed-meshheading:17991864-Humans,
pubmed-meshheading:17991864-Insulin,
pubmed-meshheading:17991864-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:17991864-Monomeric GTP-Binding Proteins,
pubmed-meshheading:17991864-Mutant Proteins,
pubmed-meshheading:17991864-Neuropeptides,
pubmed-meshheading:17991864-Phosphorylation,
pubmed-meshheading:17991864-Protein Binding,
pubmed-meshheading:17991864-Protein Kinases,
pubmed-meshheading:17991864-Protein Structure, Tertiary,
pubmed-meshheading:17991864-Proteins,
pubmed-meshheading:17991864-Recombinant Proteins,
pubmed-meshheading:17991864-Serum,
pubmed-meshheading:17991864-Signal Transduction,
pubmed-meshheading:17991864-Sirolimus,
pubmed-meshheading:17991864-TOR Serine-Threonine Kinases,
pubmed-meshheading:17991864-Tacrolimus Binding Proteins,
pubmed-meshheading:17991864-Transcription Factors
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.
|
|
pubmed:affiliation |
Department of Pharmacology, University of Pittsburgh School of Medicine, E1357 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
