| pubmed-article:17989187 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C0014644 | lld:lifeskim |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C0032520 | lld:lifeskim |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:17989187 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:17989187 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17989187 | pubmed:dateCreated | 2008-1-8 | lld:pubmed |
| pubmed-article:17989187 | pubmed:abstractText | Quantification of Epstein-Barr virus (EBV) in peripheral blood is important for the diagnosis and management of serious EBV diseases, including posttransplant lymphoproliferative disorder. A variety of PCR-based methods are currently in use; however, there is little information on their comparability. This study assessed the relative performance of different quantitative assays. A multicenter comparative study was performed at eight sites using three panels consisting of serial dilutions of quantified EBV DNA and extracts from a total of 19 whole-blood specimens. Samples were distributed and tested blindly. Instrumentation, probe chemistries, amplification targets, and other test-related aspects varied considerably between laboratories. Each laboratory's calibration curve indicated strong evidence of a consistent log-linear relationship between viral load and cycle threshold, suggesting that intralaboratory tracking of a given patient would yield similar relative quantitative trends among the participating test sites. There was strong concordance among laboratories with respect to qualitative test results; however, marked quantitative discordance was seen. For most samples, the across-laboratory interquartile range of the reported viral load (in copies/microl) was roughly 0.6 log-units, and for one sample the overall range was approximately 4.2 log-units. While intralaboratory tracking of patients may yield similar results, these data indicate a need for caution when attempting to compare clinical results obtained at different institutions and suggest the potential value to be gained by more standardized testing methodology. | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17989187 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17989187 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17989187 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17989187 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17989187 | pubmed:issn | 1098-660X | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:BalfourH... | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:CarrJJ | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:FormanM SMS | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:StevensonJJ | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:HillyardDD | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:JoshiYY | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:HodinkaR LRL | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:BankowskiM... | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:ValsamakisAA | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:BelzerS WSW | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:DiorioDD | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:HokansonK MKM | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:NikiforovaM... | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:HaydenR TRT | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:PoundsS BSB | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:RomainC ACA | lld:pubmed |
| pubmed-article:17989187 | pubmed:author | pubmed-author:U.S. EBV... | lld:pubmed |
| pubmed-article:17989187 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17989187 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:17989187 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17989187 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17989187 | pubmed:pagination | 157-63 | lld:pubmed |
| pubmed-article:17989187 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:meshHeading | pubmed-meshheading:17989187... | lld:pubmed |
| pubmed-article:17989187 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17989187 | pubmed:articleTitle | Multicenter comparison of different real-time PCR assays for quantitative detection of Epstein-Barr virus. | lld:pubmed |
| pubmed-article:17989187 | pubmed:affiliation | Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. | lld:pubmed |
| pubmed-article:17989187 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17989187 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:17989187 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17989187 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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