Linked Life Data

17988749

Source:http://linkedlifedata.com/resource/pubmed/id/17988749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2007-11-20
pubmed:abstractText
Novel findings on the effects of inflammatory molecules on neuronal circuits, and on molecular interactions between immunity and sleep, in health and disease, shed light on the pathogenesis of disorders of past (encephalitis lethargica) and present concern (human African trypanosomiasis and narcolepsy), which share alterations in sleep-wakefulness transitions. Although these three disorders differ in etiology, synaptic interactions with immune-response-derived molecules could play a pathogenetic role. Knowledge obtained on neural-immune interplay during senescence also has implications for age-related sleep dysregulation, which is common in the elderly population. Altogether, the data indicate that cell groups implicated in the regulation of sleep and wakefulness, circadian timing, and their interactions could be sensitive to synaptic effects of immune molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
645-52
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Neural-immune interactions in disorders of sleep-wakefulness organization.
pubmed:affiliation
Department of Morphological and Biomedical Sciences, Faculty of Medicine, Strada Le Grazie 8, University of Verona, Verona, Italy. marina.bentivoglio@univr.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't