|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
25
|
|
pubmed:dateCreated |
2007-12-6
|
|
pubmed:abstractText |
To develop irreversibly binding ligands for the melatonin receptor(s) as tools for tracing the primary melatonin binding site, we report on the design and synthesis of new melatoninergic azido- and isothiocyanato-substituted indoles. All active compounds were partial agonists or antagonists in the Xenopus melanophore assay, the most potent being the 5-OMe C3-substituted azido 45 and isothiocyanato 46 analogues.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
13
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6436-40
|
|
pubmed:meshHeading |
pubmed-meshheading:17988084-Animals,
pubmed-meshheading:17988084-Azides,
pubmed-meshheading:17988084-Drug Design,
pubmed-meshheading:17988084-Indoles,
pubmed-meshheading:17988084-Isothiocyanates,
pubmed-meshheading:17988084-Ligands,
pubmed-meshheading:17988084-Melatonin,
pubmed-meshheading:17988084-Receptors, Melatonin,
pubmed-meshheading:17988084-Structure-Activity Relationship,
pubmed-meshheading:17988084-Xenopus laevis
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Design, synthesis, and melatoninergic activity of new azido- and isothiocyanato-substituted indoles.
|
|
pubmed:affiliation |
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, University of Athens, Panepistimioupoli-Zografou, 157 71 Athens, Greece. tsotinis@pharm.uoa.gr
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
