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rdf:type |
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lifeskim:mentions |
umls-concept:C0016163,
umls-concept:C0027651,
umls-concept:C0162789,
umls-concept:C0178655,
umls-concept:C0441655,
umls-concept:C0442805,
umls-concept:C0936012,
umls-concept:C0995188,
umls-concept:C1414313,
umls-concept:C1516213,
umls-concept:C1527249
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pubmed:issue |
2
|
|
pubmed:dateCreated |
2008-2-15
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|
pubmed:abstractText |
EGFR (epidermal growth factor receptor) gene gain assessed by FISH (fluorescence in situ hybridization) has been shown to be predictive of response to EGFR-targeted therapies in patients with non-small cell lung cancer. The aim or our study was to relate the EGFR gene copy number to therapeutic results in patients with metastatic colorectal cancer (CRC) treated with a cetuximab-containing regimen.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1534-4681
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pubmed:author |
pubmed-author:BadettiJean-LucJL,
pubmed-author:BenchimolDanielD,
pubmed-author:CaroliFrançois-XavierFX,
pubmed-author:FollanaPhilippeP,
pubmed-author:FrançoisEricE,
pubmed-author:GarnierGeorgesG,
pubmed-author:GugenheimJeanJ,
pubmed-author:HaudebourgJulietteJ,
pubmed-author:ItalianoAntoineA,
pubmed-author:KeslairFrédériqueF,
pubmed-author:LesbatsGérardG,
pubmed-author:LledoGérardG,
pubmed-author:PedeutourFlorenceF,
pubmed-author:RousselJean-FrancoisJF
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pubmed:issnType |
Electronic
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pubmed:volume |
15
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
649-54
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17987340-Adult,
pubmed-meshheading:17987340-Aged,
pubmed-meshheading:17987340-Aged, 80 and over,
pubmed-meshheading:17987340-Antibodies, Monoclonal,
pubmed-meshheading:17987340-Antineoplastic Agents,
pubmed-meshheading:17987340-Colorectal Neoplasms,
pubmed-meshheading:17987340-Disease Progression,
pubmed-meshheading:17987340-Female,
pubmed-meshheading:17987340-Gene Dosage,
pubmed-meshheading:17987340-Humans,
pubmed-meshheading:17987340-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17987340-Male,
pubmed-meshheading:17987340-Middle Aged,
pubmed-meshheading:17987340-Patient Selection,
pubmed-meshheading:17987340-Receptor, Epidermal Growth Factor,
pubmed-meshheading:17987340-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number.
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pubmed:affiliation |
Department of Medical Oncology, Centre Antoine-Lacassagne, Canceropôle PACA, Nice, France. antoine.italiano@unice.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
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