rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-6-18
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pubmed:abstractText |
Our previous studies showed that combined treatment of oxaliplatin and N(1), N(11) diethyl-norspermine (DENSPM) results in massive induction of spermidine/spermine N(1)-acetyltransferase (SSAT) mRNA and activity. Since oxaliplatin and 5-fluorouracil (5FU) are used clinically in treatment of colorectal cancers, this study examines the effect of adding DENSPM to oxaliplatin/5FU combination on SSAT and spermine oxidase (SMO) in HCT-116 cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorouracil,
http://linkedlifedata.com/resource/pubmed/chemical/N(1),N(11)-diethylnorspermine,
http://linkedlifedata.com/resource/pubmed/chemical/Organoplatinum Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidoreductases Acting on CH-NH...,
http://linkedlifedata.com/resource/pubmed/chemical/Polyamines,
http://linkedlifedata.com/resource/pubmed/chemical/Spermine,
http://linkedlifedata.com/resource/pubmed/chemical/diamine N-acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/oxaliplatin,
http://linkedlifedata.com/resource/pubmed/chemical/polyamine oxidase
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0344-5704
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
517-27
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:17987291-Acetyltransferases,
pubmed-meshheading:17987291-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17987291-Blotting, Western,
pubmed-meshheading:17987291-Cell Line, Tumor,
pubmed-meshheading:17987291-Colonic Neoplasms,
pubmed-meshheading:17987291-Drug Synergism,
pubmed-meshheading:17987291-Fluorouracil,
pubmed-meshheading:17987291-Gene Expression,
pubmed-meshheading:17987291-Humans,
pubmed-meshheading:17987291-Organoplatinum Compounds,
pubmed-meshheading:17987291-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:17987291-Polyamines,
pubmed-meshheading:17987291-Rectal Neoplasms,
pubmed-meshheading:17987291-Spermine
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pubmed:year |
2008
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pubmed:articleTitle |
Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.
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pubmed:affiliation |
Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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